Skip to Main Content This site became the new ClinicalTrials.gov on June 19th.Show more IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health.Talk with a trusted healthcare professional before volunteering for a study.Read more... IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study.Read more... Saved Studies Saved Studies (0) Give us feedback Home Study Record Detail Comparison of Electronic Cigarettes and Tobacco Cigarettes on Cardiovascular Function and Oxidative Stress This study is currently recruiting participants.See History of Changes Background: Electronic cigarettes (e-cigarettes) are battery-powered devices heating a liquid (e-liquid) composed of propylene glycol and/or vegetable glycerin, and most commonly, nicotine to form an aerosol (vapor) that is inhaled (i.e.Scarce and conflicting data are available regarding the cardiovascular toxicity of e-cigarettes.

We wish to determine the acute effects of propylene glycol/vegetable glycerin and nicotine vaporization at high temperature in comparison to tobacco cigarette smoking on several advanced cardiovascular parameters in healthy chronic e-cigarettes users and tobacco smokers.Furthermore, a large range of plasma, urine and respiratory oxidative stress markers will be quantified.By this way, we aim to demonstrate that e-cigarettes-induced systemic oxidative stress could be linked to cardiovascular toxicity.To the best of our knowledge, this is the first project that evaluates the effects of e-cigarettes vaping in comparison to tobacco cigarette smoking on the cardiovascular system in relation to vaporization temperature, nicotine delivery and oxidative stress.Aims of the study: This study tests the following hypotheses: 1) acute high temperature vaporization of propylene glycol and vegetable glycerin has no deleterious effects on cardiovascular parameters in comparison to tobacco smoking; 2) Tobacco smoking rises plasma and urine oxidative stress biomarkers.

On the contrary, acute and chronic e-cigarettes vaping don't rise these biomarkers.At a cellular level, plasma of smokers but not vapers increases superoxide anion production.Study Type: Interventional Study Design: Allocation: RandomizedIntervention Model: Crossover AssignmentMasking: InvestigatorPrimary Purpose: Basic Science Official Title: Effects of Electronic Cigarette Vaporization at High Temperature in Comparison to Tobacco Smoking on Cardiovascular Function and Oxidative Stress in Electronic Cigarette Users and Regular Tobacco Smokers MedlinePlus related topics: E-Cigarettes U.S.FDA Resources Primary Outcome Measures: Change in subcutaneous flux [ Time Frame: 1 hour ] Secondary Outcome Measures: Change in Plasma and urine oxidative stress markers [ Time Frame: 1 hour ] Change in aortic stiffness [ Time Frame: 10 minutes ] Change in heart rate variability [ Time Frame: 10 minutes ] Change in baroreflex sensitivity [ Time Frame: 10 minutes ] Estimated Enrollment: 60 Actual Study Start Date: January 15, 2017 Estimated Study Completion Date: October 30, 2018 Estimated Primary Completion Date: June 30, 2018 (Final data collection date for primary outcome measure) Experimental: e-cigarette nic_O LT Device: e-cigarette (PG+VG without nicotine; low temperature) Experimental: e-cigarette Nic_1 LT Device: e-cigarette (PG+VG with nicotine; low temperature) Experimental: e-cigarette Nic_0 HT Device: e-cigarette (PG+VG without nicotine; high temperature) Experimental: e-cigarette NIC_1 HT Device: e-cigarette (PG+VG with nicotine; high temperature) Active Comparator: Tobacco cigarette Other: tobacco cigarette Placebo Comparator: Placebo Device: e-cigarette (PG+VG without nicotine; low temperature) Ages Eligible for Study: 18 Years to 60 Years   (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Inclusion Criteria: Healthy subjects Exclusion Criteria: Any form of cardiovascular disease Any form of pulmonary disease like asthma or COPD Any form of systemic or chronic disorder Active allergy within 4 weeks of the study Symptoms of infection or inflammation within 4 weeks of the study Pregnancy Choosing to participate in a study is an important personal decision.

Talk with your doctor and family members or friends about deciding to join a study.e cigarette kopenTo learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.e cigarette darwinFor general information, see Learn About Clinical Studies.e cigarette buy in sri lankaPlease refer to this study by its ClinicalTrials.gov identifier: NCT03036644 Contact: Philippe Van de Borne, MD, PhD +32 (0)2 555 56 64 Philippe.Van.de.Borne@erasme.ulb.ac.be Erasme Hospital Brussels, Brabant, Belgium, 1070 Study Director: Jean-Paul Van Vooren Hospital Erasme Responsible Party: Martin Chaumont, Principal investigator, Université Libre de Bruxelles ClinicalTrials.gov Identifier: NCT03036644 History of Changes Other Study ID Numbers: P2017/028 / B406201630672 Study First Received: January 27, 2017 Last Updated: February 6, 2017 Individual Participant Data Plan to Share IPD: No Studies a U.S.

FDA-regulated Drug Product: No Studies a U.S.FDA-regulated Device Product: No Keywords provided by Martin Chaumont, Université Libre de Bruxelles: electronic cigarette e-cigarette oxidative stress tobacco smoking Additional relevant MeSH terms: Nicotine Ganglionic Stimulants Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Nicotinic Agonists Cholinergic Agonists Cholinergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action To Top Copyright Privacy Accessibility Viewers and Players Freedom of Information Act USA.gov U.S.National Library of Medicine U.S.National Institutes of Health U.S.Department of Health and Human ServicesE-Selection.be Cigarette électronique Bruxelles shared a post.Taking risk in sharing this info... General Surgeon says: "Careful, reading this article, using your brain, could bring you to jail" Ice-T says: "They can't Trump with us, once we realize we're all on the same side"Une première enfin ...ÉTUDE : L’utilisation de la e-cigarette sur le long terme ne cause aucun dégât sur les poumons.