Epub 2014 Oct 21.Hecht SS1, Carmella SG2, Kotandeniya D2, Pillsbury ME2, Chen M2, Ransom BW2, Vogel RI2, Thompson E2, Murphy SE2, Hatsukami DK2.Author information1Tobacco Research Programs and Masonic Cancer Center, University of Minnesota, Minneapolis, MN hecht002@umn.edu.2Tobacco Research Programs and Masonic Cancer Center, University of Minnesota, Minneapolis, MN.AbstractINTRODUCTION: Electronic cigarettes (e-cigarettes) are rapidly increasing in popularity but little information is available on their potential toxic or carcinogenic effects.METHODS: Twenty-eight e-cigarette smokers who had not smoked tobacco cigarettes for at least 2 months provided urine samples which were analyzed by validated methods for a suite of toxicant and carcinogen metabolites including 1-hydroxypyrene (1-HOP), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), 3-hydroxypropylmercapturic acid (3-HPMA), 2-hydroxypropylmercapturic acid (2-HPMA), 3-hydroxy-1-methylpropylmercapturic acid (HMPMA), S-phenylmercapturic acid (SPMA), nicotine, and cotinine.

Levels of these compounds were compared to those found in cigarette smokers from three previous studies.RESULTS: Levels of 1-HOP, total NNAL, 3-HPMA, 2-HPMA, HMPMA, and SPMA were significantly lower in the urine of e-cigarette users compared to cigarette smokers.e-cigarette importers and distributorsLevels of nicotine and cotinine were significantly lower in e-cigarette users compared to cigarette smokers in one study but not in another.CONCLUSIONS: With respect to the compounds analyzed here, e-cigarettes have a more favorable toxicity profile than tobacco cigarettes.© The Author 2014.e cigarette operationPublished by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco.e cigarette oceanside ca

.PMID: 25335945 PMCID: PMC4481723 DOI: 10.1093/ntr/ntu218 [Indexed for MEDLINE] Free PMC ArticlePublication typesComparative StudyResearch Support, N.I.H., ExtramuralMeSH termsAcetylcysteine/analogs & derivativesAcetylcysteine/urineAdultCarcinogens/analysis*Cotinine/urineElectronic Cigarettes*FemaleHazardous Substances/urine*HumansMaleMiddle AgedNicotine/urineNitrosamines/urinePyrenes/urinePyridines/urineSmoking/urine*Tobacco Products*Young AdultSubstances3-hydroxy-1-methylpropylmercapturic acid4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olCarcinogensHazardous SubstancesNitrosaminesPyrenesPyridinesS-phenyl-N-acetylcysteineNicotineS-(3-hydroxypropyl)cysteine N-acetateCotinine1-hydroxypyreneAcetylcysteineGrant supportP30 CA077598/CA/NCI NIH HHS/United StatesR01 CA081301/CA/NCI NIH HHS/United StatesU19 CA157345/CA/NCI NIH HHS/United StatesCA77598/CA/NCI NIH HHS/United StatesFull Text SourcesSilverchair Information SystemsEurope PubMed CentralPubMed CentralPubMed Central CanadaMedicalSmoking - MedlinePlus Health InformationE-Cigarettes - MedlinePlus Health InformationMiscellaneousNICOTINE - Hazardous Substances Data BankN-ACETYLCYSTEINE - Hazardous Substances Data BankCotinine - Hazardous Substances Data Banke cigarette ambert

Epub 2016 Jun 8.Göney G1, Çok İ1, Tamer U2, Burgaz S1, Şengezer T3.Author information1a Department of Toxicology , Faculty of Pharmacy, Gazi University, Hipodrom , Ankara , Turkey .2b Department of Analytical Chemistry , Hipodrom , Ankara , Turkey , and.3c Minister of Health, Sıhhıye District Polyclinic , Sıhhıye, Ankara , Turkey.AbstractThe popularity of electronic cigarettes (e-cigarettes) is rapidly increasing in many countries.e cigarette 1400 cas d'empoisonnementThese devices are designed to imitate regular cigarettes, delivering nicotine via inhalation without combusting tobacco but currently, there is a lack of scientific evidence on the presence or absence of nicotine exposure.e cigarette vtrSuch research relies on evidence from e-cigarette users urine samples.In this study, we aimed to determine the levels and compare the amount of nicotine to which e-cigarette users, cigarette smokers and passive smokers are exposed.

Therefore, urine samples were collected from e-cigarette users, cigarette smokers, passive smokers, and healthy nonsmokers.The urinary cotinine levels of the subjects were determined using gas chromatography-mass spectrometry.The mean (±SD) urinary cotinine levels were determined as 1755 ± 1848 ng/g creatinine for 32 e-cigarette users, 1720 ± 1335 ng/g creatinine for 33 cigarette smokers and 81.42 ± 97.90 ng/g creatinine for 33 passive smokers.A significant difference has been found between cotinine levels of e-cigarette users and passive smokers (p < 0.05).There were no statistically significant differences between e-cigarette users and cigarette smokers (p > 0.05).This is a seminal study to demonstrate the e-cigarette users are exposed to nicotine as much as cigarette smokers.KEYWORDS: Cotinine; GC–MS; Turkey; e-cigarette; urinePMID: 27278718 DOI: 10.3109/15376516.2016.1144127 [Indexed for MEDLINE] MeSH termsAdultBiomarkers/urineCase-Control StudiesCotinine/urine*Creatinine/urine*Electronic Cigarettes/adverse effects*FemaleGas Chromatography-Mass SpectrometryHumansMaleNicotine*/administration & dosageNicotine*/pharmacokineticsSmoking/adverse effectsSmoking/urine*Surveys and QuestionnairesTobacco Smoke Pollution/analysis*SubstancesBiomarkersTobacco Smoke PollutionNicotineCreatinineCotinineFull Text SourcesTaylor & FrancisMedicalSmoking - MedlinePlus Health InformationCreatinine - MedlinePlus Health InformationE-Cigarettes - MedlinePlus Health InformationSecondhand Smoke - MedlinePlus Health InformationMiscellaneousNICOTINE - Hazardous Substances Data BankCotinine - Hazardous Substances Data Bank