Search for: Harvard Gazette Subscribe to the Daily Gazette Find Harvard on: Facebook | Twitter | LinkedIn Instagram | YouTube | iTunes U Science & Health  >  Health & Medicine Chemical flavorings found in e-cigarettes linked to lung disease Focus on nicotine overshadowed other hazards attached to smoking device Chemicals that create the various flavors in e-cigarettes are being linked to severe respiratory disease.Show more Email Twitter Facebook Diacetyl, a flavoring chemical linked to cases of severe respiratory disease, was found in more than 75 percent of flavored electronic cigarettes and refill liquids tested by researchers at Harvard T.H.Chan School of Public Health.Two other related, potentially harmful compounds were also found in many of the tested flavors, which included varieties with potential appeal to young people such as cotton candy, “Fruit Squirts,” and cupcake.The study was published online today in Environmental Health Perspectives.

The Occupational Safety and Health Administration and the flavoring industry have warned workers about diacetyl because of the association between inhaling the chemical and the debilitating respiratory disease bronchiolitis obliterans, colloquially known as “popcorn lung” because it first appeared in workers who inhaled artificial butter flavor in microwave popcorn processing facilities.“Recognition of the hazards associated with inhaling flavoring chemicals started with ‘popcorn lung’ over a decade ago.However, diacetyl and other related flavoring chemicals are used in many other flavors beyond butter-flavored popcorn, including fruit flavors, alcohol flavors, and, we learned in our study, candy-flavored e-cigarettes,” said lead author Joseph Allen, assistant professor of exposure assessment sciences.There are currently more than 7,000 varieties of flavored e-cigarettes and e-juice (nicotine-containing liquid that is used in refillable devices) on the market.Although the popularity and use of e-cigarettes continues to increase, there is a lack of data on their potential health effects.

E-cigarettes are not currently regulated, although the U.S.Food and Drug Administration (FDA) has issued a proposed rule to include e-cigarettes under its authority to regulate certain tobacco and nicotine-containing products.Allen and colleagues tested 51 types of flavored e-cigarettes and liquids sold by leading brands for the presence of diacetyl, acetoin, and 2,3-pentanedione, two related flavoring compounds that the Flavor and Extract Manufacturers Association lists as “high priority,” i.e., they may pose a respiratory hazard in the workplace.Each e-cigarette was inserted into a sealed chamber attached to a lab-built device that drew air through the e-cigarette for eight seconds at a time with a resting period of 15 or 30 second between each draw.The air stream was then analyzed.At least one of the three chemicals was detected in 47 of the 51 flavors tested.Diacetyl was detected above the laboratory limit of detection in 39 of the flavors tested.Acetoin and 2,3-pentanedione were detected in 46 and 23 and of the flavors, respectively.

Subscribe to the Daily Gazette Sign up for daily emails with the latest Harvard news.“Since most of the health concerns about e-cigarettes have focused on nicotine, there is still much we do not know about e-cigarettes.In addition to containing varying levels of the addictive substance nicotine, they also contain other cancer-causing chemicals, such as formaldehyde, and as our study shows, flavoring chemicals that can cause lung damage,” said study co-author David Christiani, Elkan Blout Professor of Environmental Genetics.e cigarette kangerOther Harvard Chan School authors included Skye Flanigan, Mallory LeBlanc, Jose Vallarino, Piers MacNaughton, and James Stewart.e cigarette after heart attackThis study was supported by an NIH/NIEHS Center grant.e cigarette daraz

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Epub 2015 Dec 8., , , , , , .BACKGROUND: There are > 7,000 e-cigarette flavors currently marketed.Flavoring chemicals gained notoriety in the early 2000s when inhalation exposure of the flavoring chemical diacetyl was found to be associated with a disease that became known as "popcorn lung."There has been limited research on flavoring chemicals in e-cigarettes.OBJECTIVE: We aimed to determine if the flavoring chemical diacetyl and two other high-priority flavoring chemicals, 2,3-pentanedione and acetoin, are present in a convenience sample of flavored e-cigarettes.METHODS: We selected 51 types of flavored e-cigarettes sold by leading e-cigarette brands and flavors we deemed were appealing to youth.E-cigarette contents were fully discharged and the air stream was captured and analyzed for total mass of diacetyl, 2,3-pentanedione, and acetoin, according to OSHA method 1012.RESULTS: At least one flavoring chemical was detected in 47 of 51 unique flavors tested.Diacetyl was detected above the laboratory limit of detection in 39 of the 51 flavors tested, ranging from below the limit of quantification to 239 μg/e-cigarette.